Exact genetic linkage computations for general pedigrees

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Exact genetic linkage computations for general pedigrees

MOTIVATION Genetic linkage analysis is a useful statistical tool for mapping disease genes and for associating functionality of genes with their location on the chromosome. There is a need for a program that computes multipoint likelihood on general pedigrees with many markers that also deals with two-locus disease models. RESULTS In this paper we present algorithms for performing exact multi...

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Genetic linkage mapping in complex pedigrees

Genetic linkage analysis is the primary method for the identification of loci contributing to complex disease susceptibility. Linkage analysis techniques can be applied to both disease status (discrete traits) and to quantitative trait measures (quantitative trait loci or QTL mapping). Such techniques will be most effective if they can be applied to all of the available data; in human, ecologic...

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Faster sequential genetic linkage computations.

Linkage analysis using maximum-likelihood estimation is a powerful tool for locating genes. As available data sets have grown, the computation required for analysis has grown exponentially and become a significant impediment. Others have previously shown that parallel computation is applicable to linkage analysis and can yield order-of-magnitude improvements in speed. In this paper, we demonstr...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2002

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/18.suppl_1.s189